Skip Navigation LinksHome > March 2014 - Volume 27 - Issue 3 > What are extended-spectrum beta-lactamases?
Journal of the American Academy of Physician Assistants:
doi: 10.1097/01.JAA.0000443810.42907.ec
Pharmacology Consult

What are extended-spectrum beta-lactamases?

Sutton, S. Scott PharmD, BCPS

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Abstract

ABSTRACT: The emergence and spread of extended-spectrum beta-lactamases (ESBLs) in Gram-negative bacteria pose important challenges for clinicians, as management options for these organisms are limited. The emergence of ESBL-producing Gram-negative bacteria is one of the most significant epidemiologic changes in infectious diseases during recent years. Failure to treat with an antibiotic active against ESBL-producing organisms is associated with increased patient morbidity and mortality. Carbapenems are considered the primary antibacterials for infections caused by ESBL-producing organisms but their overuse poses significant cause for concern.

© 2014 American Academy of Physician Assistants.

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