Skip Navigation LinksHome > December 2013 - Volume 21 - Issue 12 > Platelet‐rich Plasma in Orthopaedic Applications: Evidence‐b...
Journal of the American Academy of Orthopaedic Surgeons:
doi: 10.5435/JAAOS-22-08-469
Review Article

Platelet‐rich Plasma in Orthopaedic Applications: Evidence‐based Recommendations for Treatment

Hsu, Wellington K. MD; Mishra, Allan MD; Rodeo, Scott R. MD; Fu, Freddie MD; Terry, Michael A. MD; Randelli, Pietro MD; Canale, Terry S. MD; Kelly, Frank B. MD

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Abstract: Autologous platelet‐rich plasma (PRP) therapies have seen a dramatic increase in breadth and frequency of use for orthopaedic conditions in the past 5 years. Rich in many growth factors that have important implications in healing, PRP can potentially regenerate tissue via multiple mechanisms. Proposed clinical and surgical applications include spinal fusion, chondropathy, knee osteoarthritis, tendinopathy, acute and chronic soft‐tissue injuries, enhancement of healing after ligament reconstruction, and muscle strains. However, for many conditions, there is limited reliable clinical evidence to guide the use of PRP. Furthermore, classification systems and identification of differences among products are needed to understand the implications of variability.

© 2013 by American Academy of Orthopaedic Surgeons

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