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Plateletrich Plasma in Orthopaedic Applications: Evidencebased Recommendations for Treatment

Hsu, Wellington K. MD; Mishra, Allan MD; Rodeo, Scott R. MD; Fu, Freddie MD; Terry, Michael A. MD; Randelli, Pietro MD; Canale, Terry S. MD; Kelly, Frank B. MD

Journal of the American Academy of Orthopaedic Surgeons:
doi: 10.5435/JAAOS-22-08-469
Review Article
Abstract

Abstract: Autologous platelet‐rich plasma (PRP) therapies have seen a dramatic increase in breadth and frequency of use for orthopaedic conditions in the past 5 years. Rich in many growth factors that have important implications in healing, PRP can potentially regenerate tissue via multiple mechanisms. Proposed clinical and surgical applications include spinal fusion, chondropathy, knee osteoarthritis, tendinopathy, acute and chronic soft‐tissue injuries, enhancement of healing after ligament reconstruction, and muscle strains. However, for many conditions, there is limited reliable clinical evidence to guide the use of PRP. Furthermore, classification systems and identification of differences among products are needed to understand the implications of variability.

Author Information

JAAOS Plus Webinar

Join Dr. Hsu, Dr. Rodeo, and Dr. Fu for the JAAOS interactive webinar discussing “Platelet‐rich Plasma in Orthopaedic Applications: Evidencebased Recommendations for Treatment,” on Tuesday, December 10, at 9 pm Eastern. The moderator will be William N. Levine, MD, the Journals Deputy Editor for Upper Extremity topics.

To join and to submit questions in advance, please visit the OrthoPortal website: http://orthoportal.aaos.org/jaaos/

http://dx.doi.org/10.5435/JAAOS‐21–12–739

From the Department of Orthopaedic Surgery, Northwestern University Feinberg School of Medicine, Chicago, IL (Dr. Hsu and Dr. Terry), the Department of Orthopaedic Surgery, Stanford University Medical Center, Stanford, CA (Dr. Mishra), the Department of Orthopaedic Surgery and the Research Department, Hospital for Special Surgery, New York, NY (Dr. Rodeo), the Department of Orthopaedic Surgery, University of Pittsburgh, Pittsburgh, PA (Dr. Fu), the Department of Orthopaedic Surgery, University of Milan, Milan, Italy (Dr. Randelli), the Department of Orthopaedic Surgery, University of Tennessee‐Campbell Clinic, Memphis, TN (Dr. Canale), and Forsyth Street Orthopaedics, Macon, GA (Dr. Kelly).

Dr. Hsu or an immediate family member is a member of a speakers' bureau or has made paid presentations on behalf of Graftys, Medtronic Sofamor Danek, Pioneer Surgical, Stryker, Terumo Medical, and Zimmer; has received research or institutional support from Baxter, Medtronic Sofamor Danek, and Pioneer Surgical; and serves as a board member, owner, officer, or committee member of the American Academy of Orthopaedic Surgeons (AAOS), the Lumbar Spine Research Society, and the North American Spine Society. Dr. Mishra or an immediate family member has received royalties from Biomet and ThermoGenesis, is an employee of BioParadox, and has stock or stock options held in BioParadox and ThermoGenesis. Dr. Rodeo or an immediate family member serves as a paid consultant to Smith & Nephew and has stock or stock options held in Cayenne Medical. Dr. Fu or an immediate family member has received royalties from ArthroCare; is an employee of and has stock or stock options held in Stryker; and serves as a board member, owner, officer, or committee member of the AAOS, the American Orthopaedic Society for Sports Medicine, the Orthopaedic Research and Education Foundation (OREF), and the International Society of Arthroscopy, Knee Surgery, and Orthopaedic Sports Medicine. Dr. Terry or an immediate family member has received royalties from, serves as a paid consultant to, has received research or institutional support from, and has received nonincome support (such as equipment or services), commercially derived honoraria, or other non‐research‐related funding (such as paid travel) from Smith & Nephew. Dr. Randelli or an immediate family member is a member of a speakers' bureau or has made paid presentations on behalf of and has received research or institutional support from Biomet; serves as a paid consultant to DePuy; and serves as a board member, owner, officer, or committee member of the European Society of Sports Traumatology, Knee Surgery & Arthroscopy. Dr. Canale or an immediate family member serves as a board member, owner, officer, or committee member of the AAOS, Bioworks, the Campbell Foundation, and OREF. Dr. Kelly or an immediate family member serves as a board member, owner, officer, or committee member of OREF and the Twentieth Century Orthopaedic Association.

© 2013 by American Academy of Orthopaedic Surgeons

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