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Orthogenomics: An Update

Matzko, Michelle Elizabeth PhD; Bowen, Thomas R. MD; Smith, Wade R. MD

Journal of the American Academy of Orthopaedic Surgeons: August 2012 - Volume 20 - Issue 8 - p 536–546
doi: 10.5435/JAAOS-20-08-536
Review Article

The study of genomics in orthopaedics has considerably lagged behind such study in other medical disciplines. Seminal work from other lines of medical research demonstrates the importance of genomic information in the evolution of personalized medicine. Common techniques for studying genome‐phenotype associations include single nucleotide polymorphism, haplotype, and quantitative trait loci analysis. The few genome‐based studies in major orthopaedic and related conditions have focused on osteoporosis, osteoarthritis, neuropathy and nerve compression, spinal deformity, trauma and inflammatory response, and pain and analgesia. The nascent field of orthogenomics, newly defined here as the application of genomic study to orthopaedic practice, has produced findings that could affect the practice of orthopaedics. However, more work is required, and the findings must be distilled and harnessed into applicable and achievable steps to improve clinical orthopaedic practice.

From the Department of Orthopaedic Surgery, Geisinger Clinic, Danville, PA (Dr. Matzko and Dr. Bowen) and the Mountain Orthopedic Trauma Surgeons at Swedish, Englewood, CO (Dr. Smith).

Dr. Smith or an immediate family member is a member of a speakers' bureau or has made paid presentations on behalf of, serves as a paid consultant to or is an employee of, and has received research or institutional support from Synthes. Neither of the following authors nor any immediate family member has received anything of value from or holds stock or stock options in a commercial company or institution related directly or indirectly to the subject of this article: Dr. Matzko and Dr. Bowen.

© 2012 by American Academy of Orthopaedic Surgeons
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