Investigative Radiology

May 2016: Val M. Runge, MD, a note from the Editor

This issue of the journal, as always, has many outstanding articles, representing cutting edge research and technology in diagnostic imaging. Articles involving MR, CT, and spectral mammography are featured. Topics involve several areas of high interest - including specifically renal perfusion - as assessed in one study by dynamic contrast enhanced CT and in another by IVIM on MR, dynamic contrast enhanced MR of the prostate, and integrated shimming for improved lesion detection in 3 T whole body diffusion weighted MRI. Two contrast agent specific articles are also featured, both focusing on the issue of gadolinium deposition in the dentate nucleus.​

Current Issue Highlights


Val M. Runge, MD

ISSN: 0020-9996

Online ISSN: 1536-0210

Frequency: 12 issues / year

Ranking: Radiology, Nuclear Medicine, and Medical Imaging 10/125

Impact Factor: 4.437

Safety of the Gadolinium-Based Contrast Agents, A Review
​This review discusses first the background in terms of development of these agents and safety discussions therein, and second their relative stability based both on in vitro studies and clinical observations before and including the advent of nephrogenic systemic fibrosis. This sets the stage for the subsequent focus of the review, the current knowledge regarding accumulation of gadolinium in the brain and specifically the dentate nucleus after intravenous administration of the GBCAs and differentiation among agents on this basis.​