This issue of the journal, as always, has many outstanding articles, representing cutting edge research and technology in diagnostic imaging. Articles involving MR, mammography, and ultrasound are featured, with two focusing on the issue of gadolinium deposition in the body following administration of linear gadolinium chelates. Four articles are of specific note - (1) development of an innovative approach for clinical diffusion weighted imaging allowing whole brain imaging without susceptibility artifacts in under 3 minutes, (2) further investigation of dechelation with the linear gadolinium chelates in vivo and specifically determination of the chemical forms then detected in the brain, (3) a study of deep learning in mammography, demonstrating diagnostic accuracy for cancer detection with similar accuracy to radiologists , and (4) first human clinical trials with a VEGFR2-specific ultrasound molecular contrast agent, evaluated in patients with prostate cancer.

​Investigative Radiology will publish a special issue on 'Contrast Media' in 2018. The focus is on current significant advances in knowledge regarding contrast media. Relevant topics include basic science investigations, clinical trials, innovative clinical applications, and safety. With regard to clinical papers, all organ and disease areas will be considered. Submitted manuscripts should significantly advance our knowledge concerning contrast media in MR, CT, or ultrasound.

Manuscripts will be accepted for consideration beginning in October. The deadline for submission is January 31, 2018. All papers will be subject to peer review by experts in the field and must comply with the Journal's Instructions for Authors.

Val M. Runge, MD, Editor-in-Chief, Investigative Radiology

Current Issue Highlights


First-in-Human Ultrasound Molecular Imaging With a VEGFR2-Specific Ultrasound Molecular Contrast Agent (BR55) in Prostate Cancer: A Safety and Feasibility Pilot Study

Smeenge, Martijn; Tranquart, François; Mannaerts, Christophe K.; More

Investigative Radiology . 52(7):419-427, July 2017.