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Feasibility of Multiparametric Magnetic Resonance Imaging of the Prostate at 7 T

Lagemaat, Miriam W. PhD; Philips, Bart W.J. MSc, MD; Vos, Eline K. MD, PhD; van Uden, Mark J. BEng; Fütterer, Jurgen J. MD, PhD; Jenniskens, Sjoerd F. MD; Scheenen, Tom W.J. PhD; Maas, Marnix C. PhD

doi: 10.1097/RLI.0000000000000342
Technical Notes

Objectives: The aim of this study was to evaluate the technical feasibility of prostate multiparametric magnetic resonance imaging (mpMRI) at a magnetic field strength of 7 T.

Materials and Methods: In this prospective institutional review board–approved study, 14 patients with biopsy-proven prostate cancer (mean age, 65.2 years; median prostate-specific antigen [PSA], 6.2 ng/mL), all providing signed informed consent, underwent 7 T mpMRI with an external 8-channel body-array transmit coil and an endorectal receive coil between September 2013 and October 2014. Image and spectral quality of high-resolution T2-weighted (T2W) imaging (0.3 × 0.3 × 2 mm), diffusion-weighted imaging (DWI; 1.4 × 1.4 × 2 mm or 1.75 × 1.75 × 2 mm), and (1H) MR spectroscopic imaging (MRSI; real voxel size, 0.6 mm3 in 7:16 minutes) were rated on a 5-point scale by 2 radiologists and a spectroscopist.

Results: Prostate mpMRI including at least 2 of 3 MR techniques was obtained at 7 T in 13 patients in 65 ± 12 minutes. Overall T2W and DWI image quality at 7 T was scored as fair (38% and 17%, respectively) to good or very good (55% and 83%, respectively). The main artifacts for T2W imaging were motion and areas of low signal-to-noise ratio, the latter possibly caused by radiofrequency field inhomogeneities. For DWI, the primary artifact was ghosting of the rectal wall in the readout direction. Magnetic resonance spectroscopic imaging quality was rated fair or good in 56% of the acquisitions and was mainly limited by lipid contamination.

Conclusions: Multiparametric MRI of the prostate at 7 T is feasible at unprecedented spatial resolutions for T2W imaging and DWI and within clinically acceptable acquisition times for high-resolution MRSI, using the combination of an external 8-channel body-array transmit coil and an endorectal receive coil. The higher spatial resolutions can yield improved delineation of prostate anatomy, but the robustness of the techniques needs to be improved before clinical adoption of 7 T mpMRI.

From the *Department of Radiology and Nuclear Medicine, Radboud University Medical Center, Nijmegen, the Netherlands; and †Erwin L. Hahn Institute for Magnetic Resonance Imaging, University Duisburg-Essen, Essen, Germany.

Received for publication September 23, 2016; and accepted for publication, after revision, November 5, 2016.

Conflicts of interest and sources of funding: Supported by grant number 243115 from the European Research Council under the European Community's Seventh Framework Programme (FP7/2007Y2013) and by a grant of the Dutch Cancer Society (KUN 2014–6624).

The authors report no conflicts of interest.

Supplemental digital contents are available for this article. Direct URL citations appear in the printed text and are provided in the HTML and PDF versions of this article on the journal’s Web site (www.investigativeradiology.com).

Correspondence to: Tom W.J. Scheenen, PhD, Radboud University Medical Center, Geert Grooteplein 10, 6525GA Nijmegen, the Netherlands. E-mail: tom.scheenen@radboudumc.nl.

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