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Intraindividual Comparison of Diagnostic Performance in Patients With Hepatic Metastasis of Full-Dose Standard and Half-Dose Iterative Reconstructions With Dual-Source Abdominal Computed Tomography

Park, Mina MD*; Chung, Yong Eun MD, PhD*; Lee, Hye Sun MS; Choi, Jin-Young MD, PhD*; Park, Mi-Suk MD, PhD*; Kim, Myeong-Jin MD, PhD*; Kim, Ki Whang MD, PhD*

Investigative Radiology:
doi: 10.1097/RLI.0000000000000014
Original Articles

Objectives: The objectives of the study were to evaluate the image quality and diagnostic performance of sinogram-affirmed iterative reconstruction (SAFIRE) for detecting hepatic metastasis and to estimate the potential radiation dose reduction at abdominal computed tomography (CT).

Materials and Methods: Fifty-nine consecutive patients (mean age, 59.2 years; range, 42-81 years) who had hepatic metastasis and who underwent dual-source abdominal CT were enrolled in this study. The image noise of the liver was compared between full-dose filtered back projection images (FD-FBP) and simulated half-dose images, which used only single-source projection data, and reconstructed with different strengths of SAFIRE (HD-SAFIRE1-5) by 1-way analysis of variance with Bonferroni correction. The diagnostic performance for hepatic metastasis was compared by logistic regression with the weighted least squares method and noninferiority test between the FD-FBP images and the half-dose sinogram-affirmed iterative reconstruction (HD-SAFIRE) images.

Results: As the SAFIRE strength increased, image noise decreased (P < 0.001). The images of HD-SAFIRE2 showed similar image noise for liver parenchyma (13.4 Hounsfield unit [HU]), signal-to-noise ratio for liver parenchyma (9.2), and lesion-to-liver contrast-to-noise ratio (4.5), compared with the FD-FBP images (12.6 HU, P = 0.668; 9.6, P > 0.999; and 4.5, P > 0.999, respectively). The diagnostic accuracy for hepatic metastasis with the HD-SAFIRE2 images (87.5%) was not different from that of the FD-FBP images (87.5%, P > 0.999). The diagnostic performance of the HD-SAFIRE2 images was also noninferior to that of the FD-FBP images (95% confidence interval lower limit difference [−9.16%] excluding the −10% clinical noninferiority limit). The mean (SD) volume CT dose index of FD-FBP was 11.26 (2.66) mGy, and the mean (SD) radiation dose equivalent associated with HD-SAFIRE was estimated to be 5.63 (1.33) mGy.

Conclusions: By applying SAFIRE2, the radiation dose could be reduced by up to 50% compared with the standard-of-care abdominal CT protocol without increasing image noise and without deteriorating diagnostic performance for the detection of hepatic metastasis.

Author Information

From the *Department of Radiology, Research Institute of Radiological Science, and †Biostatistics Collaboration Unit, Medical Research Center, College of Medicine, Yonsei University, Seoul, South Korea.

Received for publication June 7, 2013; and accepted for publication, after revision, October 13, 2013.

Conflicts of interest and sources of funding: none declared.

Reprints: Yong Eun Chung, MD, PhD, Department of Radiology, Research Institute of Radiological Science, College of Medicine, Yonsei University, 50 Yonsei-ro, Seodaemun-gu, 120-752 Seoul, South Korea. E-mail:

© 2014 by Lippincott Williams & Wilkins