Investigative Radiology

Skip Navigation LinksHome > February 2011 - Volume 46 - Issue 2 > Multicenter Surveillance of Women at High Genetic Breast Can...
Investigative Radiology:
doi: 10.1097/RLI.0b013e3181f3fcdf
Original Article

Multicenter Surveillance of Women at High Genetic Breast Cancer Risk Using Mammography, Ultrasonography, and Contrast-Enhanced Magnetic Resonance Imaging (the High Breast Cancer Risk Italian 1 Study): Final Results

Sardanelli, Francesco MD*; Podo, Franca DrSci†; Santoro, Filippo DrSci†; Manoukian, Siranoush MD‡; Bergonzi, Silvana MD§; Trecate, Giovanna MD¶; Vergnaghi, Daniele MD¶; Federico, Massimo MD‖; Cortesi, Laura MD‖; Corcione, Stefano MD**; Morassut, Sandro MD††; Di Maggio, Cosimo MD‡‡; Cilotti, Anna MD§§; Martincich, Laura MD¶¶; Calabrese, Massimo MD‖‖; Zuiani, Chiara MD***; Preda, Lorenzo MD†††; Bonanni, Bernardo MD‡‡‡; Carbonaro, Luca A. MD*; Contegiacomo, Alma MD§§§; Panizza, Pietro MD¶¶¶; Di Cesare, Ernesto MD‖‖‖; Savarese, Antonella MD****; Crecco, Marcello MD††††; Turchetti, Daniela MD‡‡‡‡; Tonutti, Maura MD§§§§; Belli, Paolo MD¶¶¶¶; Maschio, Alessandro Del MD¶¶¶; for the High Breast Cancer Risk Italian 1 (HIBCRIT-1) Study

Collapse Box


Objectives: To prospectively compare clinical breast examination, mammography, ultrasonography, and contrast-enhanced magnetic resonance imaging (MRI) in a multicenter surveillance of high-risk women.

Materials and Methods: We enrolled asymptomatic women aged ≥25: BRCA mutation carriers; first-degree relatives of BRCA mutation carriers, and women with strong family history of breast/ovarian cancer, including those with previous personal breast cancer.

Results: A total of 18 centers enrolled 501 women and performed 1592 rounds (3.2 rounds/woman). Forty-nine screen-detected and 3 interval cancers were diagnosed: 44 invasive, 8 ductal carcinoma in situ; only 4 pT2 stage; 32 G3 grade. Of 39 patients explored for nodal status, 28 (72%) were negative. Incidence per year-woman resulted 3.3% overall, 2.1% <50, and 5.4% ≥50 years (P < 0.001), 4.3% in women with previous personal breast cancer and 2.5% in those without (P = 0.045). MRI was more sensitive (91%) than clinical breast examination (18%), mammography (50%), ultrasonography (52%), or mammography plus ultrasonography (63%) (P < 0.001). Specificity ranged 96% to 99%, positive predictive value 53% to 71%, positive likelihood ratio 24 to 52 (P not significant). MRI showed significantly better negative predictive value (99.6) and negative likelihood ratio (0.09) than those of the other modalities. At receiver operating characteristic analysis, the area under the curve of MRI (0.97) was significantly higher than that of mammography (0.83) or ultrasonography (0.82) and not significantly increased when MRI was combined with mammography and/or ultrasonography. Of 52 cancers, 16 (31%) were diagnosed only by MRI, 8 of 21 (38%) in women <50, and 8 of 31 (26%) in women ≥50 years of age.

Conclusion: MRI largely outperformed mammography, ultrasonography, and their combination for screening high-risk women below and over 50.

© 2011 Lippincott Williams & Wilkins, Inc.


Article Tools


Article Level Metrics

Search for Similar Articles
You may search for similar articles that contain these same keywords or you may modify the keyword list to augment your search.