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Sertoli Cell Tumor With Benign Peritoneal Implants Associated With Gonadoblastoma

Onida, Giovanna A. M.D.; Bosincu, Luisanna M.D., Ph.D.; Dessole, Salvatore M.D.; Nicolae, Alina M.D.; Preda, Ovidiu M.D.; Cossu-Rocca, Paolo M.D.; Aneiros-Fernandez, Jose M.D.; Nogales, Francisco F. M.D., Ph.D.

International Journal of Gynecological Pathology:
doi: 10.1097/PGP.0b013e3181dc7c2e
Pathology of the Upper Genital Tract: Case Reports

We present a unique case of bilateral gonadoblastoma in a 23-year-old patient with Swyer syndrome. The gonadoblastoma on both sides underwent synchronous neoplastic transformation, into a stage I germinoma in the right streak gonad and a highly differentiated Sertoli cell tumor in the left one. The latter was associated with a myriad of microscopic, Sertoli cell implants on the peritoneal surface, which were considered benign as they had a high grade of differentiation, minimal proliferative activity, and an absence of invasion. Most probably, the pathogenesis of this abdominal dissemination was iatrogenic, with implantation occurring mechanically as a result of the multiple laparoscopic biopsies performed on both of the streak gonads 2 months before the abdominal surgery. The pathogenesis of other benign abdominal implants is discussed.

Author Information

Department of Pathology and Obstetrics and Gynecology (G.A.O., L.B., S.D., P.C-R.), Università degli Studi di Sassari, Sardinia, Italy

Department of Pathology and Obstetrics and Gynecology (A.N., O.P., J.A-F., F.F.N.), Facultad de Medicina, Granada, Spain

Address correspondence and reprint requests to Francisco F. Nogales, MD, PhD, Department of Pathology, Facultad de Medicina, Av Madrid 11, 18012 Granada, Spain. e-mail:

©2010International Society of Gynecological Pathologists