Skip Navigation LinksHome > September 2010 - Volume 29 - Issue 5 > Sertoli Cell Tumor With Benign Peritoneal Implants Associate...
International Journal of Gynecological Pathology:
doi: 10.1097/PGP.0b013e3181dc7c2e
Pathology of the Upper Genital Tract: Case Reports

Sertoli Cell Tumor With Benign Peritoneal Implants Associated With Gonadoblastoma

Onida, Giovanna A. M.D.; Bosincu, Luisanna M.D., Ph.D.; Dessole, Salvatore M.D.; Nicolae, Alina M.D.; Preda, Ovidiu M.D.; Cossu-Rocca, Paolo M.D.; Aneiros-Fernandez, Jose M.D.; Nogales, Francisco F. M.D., Ph.D.

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Abstract

We present a unique case of bilateral gonadoblastoma in a 23-year-old patient with Swyer syndrome. The gonadoblastoma on both sides underwent synchronous neoplastic transformation, into a stage I germinoma in the right streak gonad and a highly differentiated Sertoli cell tumor in the left one. The latter was associated with a myriad of microscopic, Sertoli cell implants on the peritoneal surface, which were considered benign as they had a high grade of differentiation, minimal proliferative activity, and an absence of invasion. Most probably, the pathogenesis of this abdominal dissemination was iatrogenic, with implantation occurring mechanically as a result of the multiple laparoscopic biopsies performed on both of the streak gonads 2 months before the abdominal surgery. The pathogenesis of other benign abdominal implants is discussed.

©2010International Society of Gynecological Pathologists

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