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International Clinical Psychopharmacology:
doi: 10.1097/YIC.0000000000000026
Original article: PDF Only

Efficacy of once-daily extended release quetiapine fumarate in patients with different levels of severity of generalized anxiety disorder.

Montgomery, Stuart A.; Locklear, Julie C.; Svedsäter, Henrik; Eriksson, Hans

Published Ahead-of-Print
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Abstract

This study is a pooled, post-hoc analysis evaluating once-daily extended release quetiapine fumarate (quetiapine XR) monotherapy in patients with generalized anxiety disorder (GAD). Three previously reported positive, 8-week, randomized, double-blind, placebo-controlled studies evaluated quetiapine XR therapy (50, 150, 300 mg/day) in patients with GAD [Hamilton Anxiety Rating Scale (HAM-A) total score>=20]. Patients were stratified by baseline severity: HAM-A total score >=22, >=24, <26, >=26, >=28. We report HAM-A total score change, response (>=50% reduction in HAM-A total score), and remission (HAM-A total score<=7 and <=9). Quetiapine XR significantly improved HAM-A total scores compared with placebo at Weeks 1 and 8 in the HAM-A >=22, >=24, and >=26 cohorts (all doses), at Week 1 (all doses) and Week 8 (quetiapine XR 150 mg/day) in the <26 cohort, and at Week 1 (all doses) and Week 8 (quetiapine XR 50 and 150 mg/day) in the HAM-A>=28 group (P<0.05). Week 8 effect sizes for 50, 150, and 300 mg/day were as follows: 0.29, 0.47, 0.17 (HAM-A>=22); 0.35, 0.55, 0.22 (HAM-A>=24); 0.18, 0.32, 0.10 (HAM-A<26); 0.41, 0.59, 0.24 (HAM-A>=26); 0.60, 0.64, 0.22 (HAM-A>=28), respectively. Acute quetiapine XR monotherapy significantly improves anxiety compared with placebo in patients with moderate or severe GAD, with symptom improvements seen as early as Week 1.

(C) 2014 Wolters Kluwer Health | Lippincott Williams & Wilkins

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