Skip Navigation LinksHome > July 2013 - Volume 28 - Issue 4 > Treatment of psychotic and behavioral symptoms with clozapin...
International Clinical Psychopharmacology:
doi: 10.1097/YIC.0b013e328361e145
Case Report

Treatment of psychotic and behavioral symptoms with clozapine, aripiprazole, and reboxetine in a patient with Huntington’s disease

Edlinger, Monikaa; Seppi, Klausb; Fleischhacker, Wolfganga; Hofer, Alexa

Collapse Box

Abstract

We report on the successful use of a combined psychopharmacological treatment in a patient with Huntington’s disease, at age 39, suffering from severe psychotic and behavioral symptoms. He presented with a schizophreniform psychosis accompanied by aggressive behavior leading to admission to the locked ward of our hospital. After unsatisfactory control of the psychiatric symptoms with olanzapine, risperidone, and amisulpride, we introduced aripiprazole. This did not affect the psychotic symptoms; however, led to an improvement in aggressive behavior, motivation, and even chorea. Accordingly, we choose not to switch medication but to add clozapine. Nevertheless, his delusions improved slightly, and further add-on treatment with reboxetine brought a further beneficial effect on motivation and activities of daily living. As chorea was not disabling in our patient, tetrabenazine has not yet been tried. Treatment was safe without any relevant side effects

© 2013 Wolters Kluwer Health | Lippincott Williams & Wilkins

Login

Search for Similar Articles
You may search for similar articles that contain these same keywords or you may modify the keyword list to augment your search.