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Effect of osmotic-release oral system methylphenidate on learning skills in adolescents with attention-deficit/hyperactivity disorder: an open-label study

Na, Kyoung-Saea; Lee, Soyoung Irenea; Hong, Sungdo Davidj; Kim, Ji-Hoonb; Shim, Se-Hoonc; Choi, Jeewookd; Yang, Jaewonf; Lee, Moon-Soog; Joung, Yoo-Sookh; Kim, Eui-Jungi; Park, Joon-Hoe

International Clinical Psychopharmacology:
doi: 10.1097/YIC.0b013e3283612509
Original Articles
Abstract

We evaluated the effect of osmotic-release oral system (OROS) methylphenidate on learning skills in adolescents with attention-deficit/hyperactivity disorder (ADHD). In an open-label study, 121 adolescents with ADHD were administered flexible doses of OROS methylphenidate for 12 weeks. The efficacy of methylphenidate on ADHD symptoms was evaluated by ADHD Rating Scale (ARS) and Clinical Global Impression Scale (CGI). Learning Skills Test (LST) was used to measure the learning skills of the participants at the baseline and the endpoint. Continuous performance test, visuospatial and verbal working memory, verbal fluency, and inhibition were evaluated before and after the 12 weeks of treatment. The mean total and subscores of LST were significantly increased after the 12-week treatment with OROS methylphenidate. Executive functions were also improved during the trial, with the exception of inhibition measured by the Stroop Test. To the best of our knowledge, this is the first study to examine the influence of OROS methylphenidate on learning skill. As a result, OROS methylphenidate was effective in enhancing learning skills in adolescents with ADHD.

Author Information

aDepartment of Psychiatry, College of Medicine, Soonchunhyang University Bucheon Hospital, Bucheon

bDepartment of Psychiatry, School of Medicine, Pusan National University, Busan

cDepartment of Psychiatry, College of Medicine, Soonchunhyang University Cheonan Hospital, Cheonan

dDepartment of Psychiatry, College of Medicine, Daejeon Saint Mary’s Hospital, the Catholic University of Korea

eDepartment of Industrial and Advertising Psychology, Daejeon University, Daejeon

fDepartment of Psychiatry, Maum to Maum Clinic

gDepartment of Psychiatry, Korea University College of Medicine

hDepartment of Psychiatry, Samsung Medical Center, Sungkyunkwan University School of Medicine

iDepartment of Psychiatry, Ewha Womans University School of Medicine, Seoul, Republic of Korea

jDepartment of Health, Child and Adolescent Health Service, Western Australia, Australia

Correspondence to Soyoung Irene Lee, MD, PhD, Department of Psychiatry, College of Medicine, Soonchunhyang University Bucheon Hospital, 1174 Jung-Dong, Wonmi-Gu, Bucheon-Si, Gyeonggi-Do, 420-767 Bucheon, Republic of Korea Tel: +82 32 621 5017; fax: +82 32 621 5018; e-mail: irenelee@schmc.ac.kr

Received January 8, 2013

Accepted March 12, 2013

© 2013 Wolters Kluwer Health | Lippincott Williams & Wilkins