Skip Navigation LinksHome > May 2013 - Volume 28 - Issue 3 > No changes in striatal dopamine transporter in antidepressan...
International Clinical Psychopharmacology:
doi: 10.1097/YIC.0b013e32835ebcd7
Short Communication

No changes in striatal dopamine transporter in antidepressant-treated patients with major depression

Wu, Cheng-Kuana; Chin Chen, Kaoa,b,d; See Chen, Poa,b,d; Chiu, Nan-Tsingc; Yeh, Tzung Lieha,b; Lee, I. Huia,b; Yang, Yen Kuanga,b

Collapse Box


Selective serotonin reuptake inhibitors and serotonin norepinephrine reuptake inhibitors are the mainstay treatment for major depressive disorder, but whether their therapeutic mechanisms involve the dopaminergic system remains inconclusive. Eight participants with major depressive disorder were administered single-photon emission computed tomography with [99mTc] TRODAT-1 both before and after 24 weeks of antidepressant treatment to evaluate the change in striatal dopamine transporter (DAT) availability. All participants were responders (≥50% reduction in Hamilton Depression Rating Scale score). The DAT availability did not change (P=0.58), as the Hamilton Depression Rating Scale score decreased (P=0.02). Striatal DAT availability remains intact during long-term antidepressant treatment in patients with major depressive disorder.

© 2013 Lippincott Williams & Wilkins, Inc.


Article Tools


Article Level Metrics

Search for Similar Articles
You may search for similar articles that contain these same keywords or you may modify the keyword list to augment your search.