Skip Navigation LinksHome > September 2011 - Volume 26 - Issue 5 > Comparison of agomelatine and escitalopram on nighttime slee...
International Clinical Psychopharmacology:
doi: 10.1097/YIC.0b013e328349b117
Original Articles

Comparison of agomelatine and escitalopram on nighttime sleep and daytime condition and efficacy in major depressive disorder patients

Quera-Salva, Maria-Antoniaa; Hajak, Goerand; Philip, Pierreb; Montplaisir, Jaquese; Keufer-Le Gall, Sophiec; Laredo, Judithc; Guilleminault, Christianf

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Agomelatine, an MT1/MT2 receptor agonist and 5-HT2C receptor antagonist antidepressant, is known to have beneficial effects on subjective sleep in major depressive disorder patients. This international multicenter, randomized, double-blind study compared the effects of agomelatine (25–50 mg/day) and escitalopram (10–20 mg/day) on sleep polysomnographic parameters in major depressive disorder patients treated up to 24 weeks. A total of 138 outpatients were randomly allocated to agomelatine (n=71) or escitalopram (n=67). Treatment with agomelatine was associated with a reduction in sleep latency from week 2 onward. The difference between treatments was significant on all evaluations. Rapid eye movement latency was increased with escitalopram compared with agomelatine, with significant between-group differences at every visit. Agomelatine preserved the number of sleep cycles, whereas it was decreased with escitalopram with significant between-group differences at every visit. Assessments on visual analogue scales indicated that treatment with agomelatine improved morning condition, and reduced daytime sleepiness compared with escitalopram.

17-item Hamilton depression rating scale total score was reduced in both groups, agomelatine was statistically noninferior to escitalopram at 6 weeks. Both treatments were well tolerated. This study showed that the clinical effects of agomelatine on sleep and wake parameters are different from that of escitalopram.

© 2011 Lippincott Williams & Wilkins, Inc.


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