Skip Navigation LinksHome > May 2011 - Volume 26 - Issue 3 > Antidepressant use, depression, lifestyle factors, and new-o...
International Clinical Psychopharmacology:
doi: 10.1097/YIC.0b013e328342ce31
Original Articles

Antidepressant use, depression, lifestyle factors, and new-onset diabetes

Wilkins, Tricia Leea; Sambamoorthi, Ushaa,b

Collapse Box


We assessed the short-term association between antidepressant drug use and the risk of new-onset diabetes in 2-years of observation. This study used longitudinal data from the Medical Expenditure Panel Survey for years 2004–2007. Chi-square tests and logistic regressions were used to examine the link between use of antidepressants with and without depression, and new-onset diabetes, after controlling for independent variables in blocks. In unadjusted models, the risk of new-onset diabetes was significantly increased for persons using antidepressants with depression compared with those without antidepressant use or depression [odds ratio (OR)=2.12, 95% confidence interval (CI): 1.45–3.09]. When lifestyle risk factors were entered in the model, statistical significance disappeared [adjusted OR (AOR)=1.42, 95% CI: 0.98–2.08]. Independently, lifestyle risk factors significantly increased the risk of new-onset diabetes: hypertension (AOR=2.55, 95% CI: 1.86–3.50, P<0.001), lipid disorders (AOR=1.60, 95% CI: 1.14–2.24), overweight (AOR=2.01, 95% CI: 1.35–2.98), obesity (AOR=3.57, 95% CI: 2.50–5.10), and no physical exercise (AOR=1.98, 95% CI: 1.53–2.57, P<0.001). Future studies on the risk of new-onset diabetes by duration and intensity of antidepressant use and depression are needed.

© 2011 Lippincott Williams & Wilkins, Inc.


Article Tools


Article Level Metrics

Search for Similar Articles
You may search for similar articles that contain these same keywords or you may modify the keyword list to augment your search.