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Antidepressant use, depression, lifestyle factors, and new-onset diabetes

Wilkins, Tricia Leea; Sambamoorthi, Ushaa,b

International Clinical Psychopharmacology: May 2011 - Volume 26 - Issue 3 - p 159–168
doi: 10.1097/YIC.0b013e328342ce31
Original Articles

We assessed the short-term association between antidepressant drug use and the risk of new-onset diabetes in 2-years of observation. This study used longitudinal data from the Medical Expenditure Panel Survey for years 2004–2007. Chi-square tests and logistic regressions were used to examine the link between use of antidepressants with and without depression, and new-onset diabetes, after controlling for independent variables in blocks. In unadjusted models, the risk of new-onset diabetes was significantly increased for persons using antidepressants with depression compared with those without antidepressant use or depression [odds ratio (OR)=2.12, 95% confidence interval (CI): 1.45–3.09]. When lifestyle risk factors were entered in the model, statistical significance disappeared [adjusted OR (AOR)=1.42, 95% CI: 0.98–2.08]. Independently, lifestyle risk factors significantly increased the risk of new-onset diabetes: hypertension (AOR=2.55, 95% CI: 1.86–3.50, P<0.001), lipid disorders (AOR=1.60, 95% CI: 1.14–2.24), overweight (AOR=2.01, 95% CI: 1.35–2.98), obesity (AOR=3.57, 95% CI: 2.50–5.10), and no physical exercise (AOR=1.98, 95% CI: 1.53–2.57, P<0.001). Future studies on the risk of new-onset diabetes by duration and intensity of antidepressant use and depression are needed.

aSchool of Pharmacy, Department of Pharmaceutical Systems and Policy, West Virginia University, Morgantown, West Virginia

bDepartment of Community Health and Preventive Medicine, Morehouse School of Medicine, Atlanta, Georgia, USA

Correspondence to Dr Tricia Lee Wilkins, Pharm D, School of Pharmacy, West Virginia University, Robert C. Byrd Health Sciences Center, PO Box 9510, Morgantown, WV 26505, USA Tel: +1 304 293 6991; fax: +1 304 293 2529; e-mail:

The findings and opinions reported here are those of the authors and do not necessarily represent the views of any other individuals or organizations.

Received June 1, 2010

Accepted November 18, 2010

© 2011 Lippincott Williams & Wilkins, Inc.