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Norepinephrine transporter gene (SLC6A2) is involved with methylphenidate response in Korean children with attention deficit hyperactivity disorder

Song, Jungeuna; Song, Dong-Hob; Jhung, Kyungunb; Cheon, Keun-Ahb

International Clinical Psychopharmacology: March 2011 - Volume 26 - Issue 2 - p 107–113
doi: 10.1097/YIC.0b013e32834152d1
Original Articles

The purpose of this study was to investigate the association between the methylphenidate (MPH) response and the norepinephrine transporter (NET) gene polymorphisms in Korean children with attention deficit hyperactivity disorder (ADHD). One hundred and fourteen children with ADHD (mean age 9.08±1.94 years) were recruited from a child psychiatric clinic in South Korea. The genomic DNA was extracted from the blood lymphocyte. Patients were administered MPH for 8 weeks. Good response was defined as a decrease of more than 50% from the baseline ADHD rating scale-IV scores or Clinical Global Impression-Severity score was 1 or 2 after treatment. We compared the MPH response according to the genotype of G1287A of the NET gene (SLC6A2). In patients with G/G genotype, 41 patients (71.9%) showed good response and 16 patients (28.1%) showed poor response when it was measured by the ADHD rating scale-IV. In comparison, 23 patients (46.0%) with G/A genotype and four patients (57.1%) with A/A genotype showed good response (P=0.018, by the Fisher's exact test). When we compared the response of MPH between patients with G/G genotype and those without G/G genotype, 41 patients (71.9%) with G/G genotype showed good response, whereas only 27 patients (46.4%) without G/G genotype showed good response. [Pearson χ2=7.143, degrees of freedom (df)=1, P=0.008]. Our study found a significant association between the G1287A genotype of the NET gene and the MPH response in Korean children with ADHD. These findings support the significant role of the NET gene in ADHD treatment with MPH.

aDepartment of Psychiatry, Kwandong University College of Medicine, Myong-ji Hospital, Kyunggi

bDepartment of Child and Adolescent Psychiatry and Institute of Behavioral Science in Medicine, Severance Children's Hospital, Yonsei University College of Medicine, Seoul, Korea

Correspondence to Dr Keun-Ah Cheon, MD, PhD, Department of Child and Adolescent Psychiatry and Institute of Behavioral Science in Medicine, Severance Children's Hospital, Yonsei University College of Medicine, 250 Seongsanno, Seodaemun-Gu, Seoul 120-752, South Korea Tel: +822 2228 1633, fax: +822 313 0891; e-mail: kacheon@yuhs.acJungeun

Song and Dong-Ho Song contributed equally to this study

Received June 19, 2010

Accepted October 7, 2010

© 2011 Lippincott Williams & Wilkins, Inc.