You could be reading the full-text of this article now if you...

If you have access to this article through your institution,
you can view this article in

Dosage of conventional neuroleptic medication and subjective cognitive functioning in schizophrenia.

Krausz, M.; Moritz, S.; Lambert, M.; Naber, D.
International Clinical Psychopharmacology:
RESEARCH REPORTS: PDF Only
Abstract

: Subjective cognitive and perceptual disturbances as assessed with the Frankfurt Complaint Questionnaire (FCQ) were correlated with chlorpromazine equivalents in 40 schizophrenic inpatients, who were treated with conventional neuroleptics. In line with previous research using 'objective' neuropsychological tests, both correlations and partial correlations (controlling for the effects of psychopathology, extrapyramidal symptoms and length of illness) confirmed that higher neuroleptic doses significantly worsen several cognitive and perceptual domains (r = 0.44 -0.54; P <= 0.005 -0.05) with the possible exception of mnestic functions (r = 0.21 - 0.24, n.s.) and language (r = 0.37 -0.38, P <= 0.1). The clinical importance of self-report scales for evaluating both the risks and benefits of neuroleptic treatment is discussed.

(C) 2000 Lippincott Williams & Wilkins, Inc.