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Hybrid Repair of Thoracic and Thoracoabdominal Aortic Aneurysms (Mega Aortic Syndrome) With Lupiae Technique

Esposito, Giampiero MD; Cappabianca, Giangiuseppe MD; Contegiacomo, Gaetano MD; Labriola, Giuseppe MD; Gallo, Nunzio MD; Labriola, Cataldo MD

Innovations:Technology and Techniques in Cardiothoracic and Vascular Surgery: November/December 2011 - Volume 6 - Issue 6 - p 366–372
doi: 10.1097/IMI.0b013e318247fb71
Original Articles

Objective: Several techniques have been described for the treatment of thoracic and thoracoabdominal aneurysms in patients with mega aortic syndrome (MAS), but the incidence of stroke, spinal cord injury, and endoleaks remains high. We present the midterm results of a new hybrid, multistep technique to treat patients with MAS.

Methods: From November 2005 to January 2011, 80 patients with MAS underwent hybrid repair of thoracic and thoracoabdominal aneurysms with the Lupiae technique. Forty-six patients presented with chronic aortic aneurysms, and 34 patients who had undergone aortic arch debranching with the Lupiae graft for acute aortic dissection presented with an expanding false lumen into the residual aorta. Sixty patients underwent ascending aorta and arch replacement with a Gelweave Lupiae prosthesis plus epiaortic vessel debranching (thoracic Lupiae procedure). Fourteen patients underwent a thoracic Lupiae procedure plus partial visceral debranching (celiac trunk and superior mesenteric artery) through a mini-laparotomy. Six patients underwent a thoracic Lupiae procedure plus a complete visceral debranching (celiac trunk, superior mesenteric artery, and renal arteries) with the implant of a second Lupiae prosthesis to replace the abdominal aorta. After the surgical steps, all the surviving patients underwent an endovascular procedure to implant multiple stent grafts to exclude the residual segment of diseased aorta.

Results: In-hospital mortality was 8.4%, and the incidence of temporary renal failure was 5.2%. None of the patients had a stroke or a spinal cord injury, and none of the patients presented endoleaks immediately following the procedure or during the follow-up computed tomography scans. No deaths occurred during the 6-year follow-up after the hybrid procedure.

Conclusions: These preliminary results showed that the Lupiae technique is a safe and effective option for the treatment of patients with MAS. Indeed, the Lupiae technique achieves complete exclusion of thoracic and thoracoabdominal aneurysms with a low risk of paraplegia and endoleaks.

From the Cardiovascular Surgery Unit, Santa Maria Hospital, Bari, Italy.

Accepted for publication December 12, 2011.

Presented at the Annual Scientific Meeting of the International Society for Minimally Invasive Cardiothoracic Surgery, June 8–11, 2011, Washington, DC USA.

Disclosure: The authors declare no conflict of interest.

Address correspondence and reprint requests to Giampiero Esposito, MD, Cardiovascular Surgery Unit, Humanitas Gavazzeni Hospital, Via M. Gavazzeni n. 21, Bergamo, Italy. E-mail:

© 2011 Lippincott Williams & Wilkins, Inc.