Known to mostly cause mild disease, Bordetella holmesii most often presents clinically as bacteremia, with occasional patients also having respiratory illness. In most instances, infected patients are immunocompromised, with anatomical or functional asplenia being the most common undeerlying condition. Bush et al. describe the first case of prosthetic valve enodcarditis due to this rare pathogen. A propos this case, they review the clinical manifestations, microbiologic profile and treatment options for B. homesii.