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Oral Serum-Derived Bovine Immunoglobulin for Management of Infectious Diarrhea due to Norovirus and Cryptosporidiosis in Solid Organ Transplant Patients

Gelfand, Michael S. MD; Cleveland, Kerry O. MD

Infectious Diseases in Clinical Practice: July 2017 - Volume 25 - Issue 4 - p 218–220
doi: 10.1097/IPC.0000000000000479
Case Reports

Abstract: Diarrhea and its sequelae are commonly seen in renal transplant recipients. Current effective options to treat many causes of infectious diarrhea in this population are limited. Oral serum-derived bovine immunoglobulin was recently successfully used to manage 2 renal transplant patients with diarrhea due to cryptosporidiosis and norovirus infection, respectively.

Diarrhea and its sequelae are commonly seen in renal transplant recipients. Current effective options to treat many causes of infectious diarrhea in this population are limited. Oral serum-derived bovine immunoglobulin was recently successfully used to manage two renal transplant patients with diarrhea due to cryptosporidiosis and norovirus infection, respectively.

From the Department of Medicine, Division of Infectious Diseases, University of Tennessee Health Science Center, Memphis, TN.

Correspondence to: Kerry O. Cleveland, MD, Department of Medicine, Division of Infectious Diseases, University of Tennessee Health Science Center, 1325 Eastmoreland Ave, Suite 460, Memphis, TN 38104. E-mail: kcleveland@uthsc.edu.

M.S.G. has served as a speaker for EnteraHealth, Inc. The other author has no funding or conflicts of interest to disclose.

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