Vibrio parahaemolyticus is a gram-negative bacterium that may be associated with the ingestion of seafood, presenting with gastroenteritis, wound infection, or septicemia. In this case, the report of a patient with septicemia and abdominal compartment syndrome, likely associated with V. parahaemolyticus infection, with no apparent compromise of the immune system is presented. Septicemia in the setting of Vibrio infection usually occurs in those with underlying liver disease or immune compromise. Abdominal compartment syndrome developed in this case, requiring surgical decompression. The prompt use of appropriate antibiotics, emergent surgical decompression to relieve the patient’s abdominal compartment syndrome, and aggressive supportive intensive care unit care were ultimately lifesaving interventions in this patient with overwhelming sepsis.