Epidural Pneumatosis Complicating Pneumocystis jiroveci Pneumonia in a Patient With AIDSTomal, Justin BA; Shah, Nirav MD, MPH; Schneider, John MD, MPHInfectious Diseases in Clinical Practice: July 2014 - Volume 22 - Issue 4 - p e44–e46 doi: 10.1097/IPC.0b013e3182948e8f Case Reports Abstract Author Information Abstract: Here, we report what is to our knowledge the first documented case of epidural pneumatosis in the setting of Pneumocystis jiroveci pneumonia. Epidural pneumatosis is defined by air in the epidural space. Its common pathophysiologic development is from air leaking from pneumomediastinum through intervertebral foramina, although other mechanisms exist. Our patient, an 18-year-old man with acquired immunodeficiency syndrome, developed a striking epidural pneumatosis with associated pneumomediastinum as a complication of P jiroveci pneumonia. He was treated successfully with trimethoprim-sulfamethoxazole and prednisone, and he experienced no sequelae from the epidural pneumatosis. In fact, epidural pneumatosis generally is regarded as a benign phenomenon. From the Section of Infectious Diseases, Department of Medicine, University of Chicago, Chicago, IL. Correspondence to: Justin Tomal, BA, Section of Infectious Diseases, Department of Medicine, University of Chicago, 5841 S Maryland Ave, Chicago, IL 60637. E-mail: firstname.lastname@example.org. The authors have no funding or conflicts of interest to disclose. © 2014 by Lippincott Williams & Wilkins.