Abstract: Desert rheumatism is a common phenomenon in endemic regions. It is also known as “Valley fever,” “California fever,” and “San Joaquin Valley fever.” It is described as a triad of fever, erythema nodosum, and arthralgias and is caused by Coccidioides species. Coccidioides-related infections are commonly seen in southwest areas of United States, Mexico, and Latin America. Coccidiomycosis outside the endemic regions is not common and its diagnosis often delayed. We report a case of a 29-year old immunocompetent female who presented with desert rheumatism after a travel to an endemic region.