Two cases of Candida albicans infections following total hip replacement are presented. The first case describes a patient with bilateral hip prosthesis and peritoneal dialysis. Revision surgery of the left hip, with exchange of a loosened acetabular cup, revealed C. albicans in 5 tissue specimens. This prosthetic infection was probably a result of hematogenous seeding from an infected peritoneal dialysis catheter. The second case describes a patient who had C. albicans superinfection after 2 surgical revisions on early deep infection following a primary total hip replacement. Direct inoculation of skin microflora at time of surgery is the most probable explanation. Both patients had predisposing factors as comorbidities and complicated prosthetic surgery. Treatment was a combination of revision surgery and antimicrobial therapy with fluconazole.