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Cytomegalovirus Encephalitis in an Allogeneic Hematopoietic Cell Transplant Recipient: A Case Report and Review of Literature

Yacoub, Abraham MD*; Besaw, Laura ARNP*; Pasikhova, Yanina PharmD; Kharfan-Dabaja, Mohamed A. MD; Sandin, Ramon L. MD, MS, FCAP§; Greene, John MD, FACP*

Infectious Diseases in Clinical Practice: July 2014 - Volume 22 - Issue 4 - p e95–e99
doi: 10.1097/IPC.0000000000000156
Case Reports

Cytomegalovirus (CMV) commonly reactivates in seropositive recipients after allogeneic hematopoietic cell transplant but rarely causes infection. Since the implementation of preemptive approaches, infection by CMV has become a rare occurrence. We describe the successful treatment of a case of late ganciclovir-resistant CMV encephalitis occurring 2 ½ years after an HLA-mismatched allogeneic hematopoietic stem cell transplant.

From the *H. Lee Moffitt Cancer Center and Research Institute, University of South Florida College of Medicine; and †Infectious Diseases, ‡Department of Blood and Marrow Transplantation, and §Clinical Microbiology and Virology Laboratories, Moffitt Cancer Center, University of South Florida College of Medicine, Tampa, FL.

Correspondence to: John Greene, MD, FACP, H. Lee Moffitt Cancer Center and Research Institute, University of South Florida College of Medicine, 12902 Magnolia Drive, Tampa, FL. E-mail: john.greene@moffitt.org.

The authors have no funding or conflicts of interest to disclose.

© 2014 by Lippincott Williams & Wilkins.