Skip Navigation LinksHome > July 2014 - Volume 22 - Issue 4 > Clostridium difficile Osteomyelitis Associated With Methotre...
Infectious Diseases in Clinical Practice:
doi: 10.1097/IPC.0b013e3182a0e968
Case Reports

Clostridium difficile Osteomyelitis Associated With Methotrexate Use: A Case Report

Chizea, Chike T.E. MBBS, MPH, CPH*; Apuri, Susmitha MD; DeRespino, Allison MS, MD; Kelkar, Dhanashree MD§; Greene, John N. MD, FACP

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Abstract: Clostridium difficile (C difficile) is a gram-positive anaerobic spore-forming bacillus that usually causes pseudomembranous colitis. It is a normal commensal of the gastrointestinal tract but grows excessively when antibiotics inhibit other normal gastrointestinal tract flora. Clinical manifestations are mostly gastrointestinal in origin secondary to toxin production, but it can also present with extracolonic infections such as osteomyelitis, making the diagnosis complex. Here, we present a rare case of such a manifestation not caused by the “usual suspects”, i.e., prolonged antibiotic use and hospital admission but by an antineoplastic medication.

© 2014 by Lippincott Williams & Wilkins.

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