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Chronic Recurrent Multifocal Osteomyelitis Mimicking Infection

Yacoub, Abraham T. MD; Khwaja, Sara I. MD, MS; Greene, John N. MD, FACP

Infectious Diseases in Clinical Practice:
doi: 10.1097/IPC.0000000000000152
Case Reports

Abstract: Chronic recurrent multifocal osteomyelitis (CRMO) is commonly confused with hematogenous bacterial osteomyelitis. It is a rare, inherited, autoinflammatory disease of children, adolescents, and occasionally, adults. The CRMO causes focal skeletal pain and tenderness at the site of inflammation that can greatly limit physical activity. We present 2 patients of CRMO who underwent an extensive workup to rule out an infectious cause.

Author Information

From the H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL.

Correspondence to: John N. Greene, MD, FACP, H. Lee Moffitt Cancer Center and Research Institute, 12902 Magnolia Drive, FOB-3, Tampa, FL 33612-9497. E-mail:

The authors have funding or conflicts of interest to disclose.

© 2014 by Lippincott Williams & Wilkins.