We report a case of methicillin-resistant Staphylococcus aureus bacteremia and proven prosthetic valve endocarditis successfully treated with ceftaroline salvage therapy after clinical failure with daptomycin. The patient, allergic to vancomycin, was treated with daptomycin as monotherapy and in combination with nafcillin and gentamicin. She was found to have recurrent bacteremia and a vegetation on her bioprosthetic mitral valve. On the third day of treatment with ceftaroline, repeat blood cultures were negative. Imaging performed after the course of ceftaroline showed resolution of the vegetation. Our case documents the safety and efficacy of ceftaroline in bacteremia and prosthetic valve endocarditis.