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Treatment of Disseminated Rhizomucor With a Combination of Ambisome and Posaconazole

Pak, Jane MD*; Tucci, Veronica T. JD, MD*; Katayama, Mitsuya MD*; Vincent, Albert L. PhD*; Sandin, Ramon L. MD, MS†§; Greene, John N. MD‡∥

Infectious Diseases in Clinical Practice: March 2014 - Volume 22 - Issue 2 - p 65–67
doi: 10.1097/IPC.0b013e31828941d5
Review Articles

Abstract: Although rare in the general population, mucormycosis can become a rapidly progressive and lethal opportunistic infection in the ketone and carbohydrate-rich milieu of diabetes mellitus and in other conditions. In the past 2 decades, an increasing number of mucormycosis cases have appeared after immunosuppressive treatment for leukemia or bone marrow transplant. We present a case of a patient with acute lymphoblastic leukemia who developed extensively disseminated Rhizomucor infection after chemotherapy. We also discuss the etiology, epidemiology, presentations, diagnoses, and treatment of these increasingly common mucormycosis infections.

From the *Division of Infectious Diseases and International Medicine, Department of Internal Medicine, College of Medicine, University of South Florida; †Clinical Microbiology and Virology Laboratories, H. Lee Moffitt Cancer Center and Research Institute; ‡Division of Infectious Diseases, §Department of Pathology, College of Medicine, University of South Florida; and ∥H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL.

Correspondence to: John N. Greene, MD, H. Lee Moffitt Cancer Center and Research Institute; College of Medicine, University of South Florida, 12902 Magnolia Dr, Tampa, FL 33612-9497. E-mail: john.greene@moffitt.org.

The authors have no funding or conflicts of interest to disclose.

© 2014 by Lippincott Williams & Wilkins.