Vancomycin-resistant enterococci (VRE) are a significant cause of bloodstream infections (BSIs) and mortality in patients with acute myelogenous leukemia undergoing chemotherapy or allogeneic hematopoietic stem cell transplant (HSCT). Fecal colonization with VRE is a major risk factor for development of VRE BSIs in neutropenic patients with a hematologic malignancy. Mucosal damage and neutropenia from high-dose chemotherapeutic agents allow enteric VRE to enter the systemic circulation via translocation resulting in a BSI. Recent studies have shown that 13.4% of VRE-colonized cancer patients and 34.2% of VRE-colonized patients who underwent allogeneic hematopoietic stem cell transplant developed VRE BSI, and a large percentage of these patients die from this infection. Here, we show that empiric or prophylactic treatment with daptomycin significantly reduces the percentage of VRE-colonized patients with acute myelogenous leukemia who will go on to develop BSIs after immunosuppressive treatment. In addition, we found a significant reduction in mortality caused by VRE BSIs in this patient population.