Klebsiella pneumoniae is a Gram-negative bacillus with a strong presence in the health care setting. Carbapenem-resistant strains of K pneumoniae (KPC) have recently become an increasing cause of nosocomial morbidity and mortality. In an era that has witnessed the production of bacteria highly resistant to conventional antibiotics, atypical sites of infection are often caused by multidrug-resistant pathogens, further complicating treatment of infectious diseases.Klebsiella pneumoniae is rarely a cause of endocarditis; however, in patients with KPC bacteremia, physicians should be aware of the possibility of KPC endocarditis. The presence of KPC endocarditis should prompt surgical evaluation in addition to targeted antibiotic therapy. This is, to our knowledge, the first reported case of prosthetic valve KPC endocarditis.