A 63-year-old man sought medical attention after enduring unremitting backache for 2 months. There was no history of trauma or systemic illness. Result of workup for malignancies was negative, and imaging studies were suggestive of thoracic spondylodiscitis. The patient underwent spinal computed tomography–guided sample, and cultures grew out Eikenella corrodens that was further confirmed by polymerase chain reaction assay. The patient responded well to ampicillin and amoxicillin-clavulanate and recovered without any surgical intervention. Spinal infections due to E corrodens are uncommon. If diagnosed properly by culture from tissue sample of the vertebral lesion, Eikenella spondylodiscitis can be treated successfully with appropriate antibiotics alone despite the severity of the vertebral lesions. We reported a unique case with a molecular detection of E corrodens from a spinal sample.