The disease burden from tuberculosis (TB) and diabetes mellitus (DM) is increasing globally. Current evidence suggests that DM increases the odds of developing TB. This risk is highest in the low- and middle-income countries, where the burden of TB is high. Immune dysfunction due to DM increases the propensity to develop TB. Both DM and TB complicate each other and present enormous clinical challenges. This review article discusses the close interaction between the 2 comorbidities and also advocate for consideration of integration of dual-screening strategies for DM and TB in clinical care especially in areas with high prevalence of both diseases.