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Tuberculosis and Diabetes Mellitus Interaction: A Current Clinical Perspective

Kibirige, Davis MBChB, MMed Internal Medicine*; Ssekitoleko, Richard MBChB, MMed Internal Medicine†‡; Worodria, William MBChB, MMed Internal Medicine, PhD‡§

Infectious Diseases in Clinical Practice:
doi: 10.1097/IPC.0b013e31828f4b53
Review Articles

Abstract: The disease burden from tuberculosis (TB) and diabetes mellitus (DM) is increasing globally. Current evidence suggests that DM increases the odds of developing TB. This risk is highest in the low- and middle-income countries, where the burden of TB is high. Immune dysfunction due to DM increases the propensity to develop TB. Both DM and TB complicate each other and present enormous clinical challenges. This review article discusses the close interaction between the 2 comorbidities and also advocate for consideration of integration of dual-screening strategies for DM and TB in clinical care especially in areas with high prevalence of both diseases.

Author Information

From the *Department of Medicine, St Raphael of St Francis Hospital Nsambya; †Infectious Diseases Unit, Mulago National Referral and Teaching Hospital; ‡Department of Medicine, Makerere University College of Health Sciences; and §Pulmonology Unit, Mulago National Referral and Teaching Hospital, Kampala, Uganda.

Correspondence to: Davis Kibirige, MBChB, MMed Internal Medicine, Department of Medicine, St Raphael of St Francis Hospital Nsambya, PO Box 7146, Kampala, Uganda. E-mail:

The authors have no funding or conflicts of interest to disclose.

© 2013 by Lippincott Williams & Wilkins.