Abstract: Kocuria species are members of skin and oral microflora and generally regarded as nonpathogenic colonization. These organisms commonly cause invasive device-related infections, especially in patients who have underlying chronic disease. Up to now, infective endocarditis caused by Kocuria species was documented only in one immunocompromised patient who had predisposing factors as central venous catheter. We describe the first case of infective endocarditis caused by Kocuria kristinae involving 2 native valves in a diabetic patient without implantable invasive device. It was successfully controlled with antibacterial therapy and replacement of mitral and aortic valves. Unusual microorganisms such as K kristinae should be kept in mind as a cause of infective endocarditis also in patients without implantable invasive device.