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Gastric Mucormycosis Managed With Combination Antifungal Therapy and No Surgical Debridement

Katta, Joseph MD*; Gompf, Sandra G. MD, FACP; Narach, Tienchai MD*; Poetter, Daniel MD; Kulkarni, Prasad MD§; Reed, Jennifer MD; Goldsmith, Susan F. MD

Infectious Diseases in Clinical Practice: July 2013 - Volume 21 - Issue 4 - p 265–268
doi: 10.1097/IPC.0b013e31826e81b3
Case Reports

Abstract: Invasive zygomycosis is the second most common opportunistic mold infection after invasive aspergillosis among patients with hematological malignancies and transplant recipients, and cure typically requires extensive debridement. Gastric zygomycosis is infrequently reported yet highly lethal, despite aggressive interventions that include gastrectomy and extended intravenous antifungal therapy. We believe ours to be the second reported case of gastric zygomycosis cured without the morbidity of gastrectomy, using extended lipid-based amphotericin B and posaconazole.

From the *Division of Infectious Diseases and International Medicine, University of South Florida Morsani College of Medicine; †Infectious Disease Section, James A. Haley Veterans Hospital; Infectious Diseases and International Medicine, University of South Florida Morsani College of Medicine; ‡James A. Haley Veterans Hospital; Department of Internal Medicine, University of South Florida Morsani College of Medicine; §James A Haley Veterans Hospital; Division of Digestive Diseases and Nutrition, University of South Florida Morsani College of Medicine; ∥James A. Haley Veterans Hospital; Department of Pathology and Cell Biology, University of South Florida College of Medicine and ¶Digestive Diseases and Nutrition, James A. Haley Veterans Hospital and the University of South Florida College of Medicine, Tampa, FL.

Correspondence to: Sandra G. Gompf, MD, Infectious Disease Section, James A. Haley Veterans Hospital; Infectious Diseases and International Medicine, University of South Florida Morsani College of Medicine, 13000 Bruce B. Downs Blvd, 111J, Tampa, FL 33612. E-mail: sandra.gompf@va.gov.

The authors have no funding or conflicts of interest to disclose.

This case was submitted as a non–peer-reviewed abstract to the 76th Annual Scientific Meeting of the American College of Gastroenterology, October 15–20, 2010.

© 2013 by Lippincott Williams & Wilkins.