Acute Liver Failure Secondary to Herpes Simplex Virus Hepatitis in an Immunocompromised Patient With Human Immunodeficiency VirusFebles-Negrón, Arelis MD*; Carrillo-Morales, Sol MD*; Billoch-Lima, Jorge MD†; Santé-Pérez, María MD, FCAP†; Bertrán-Pasarell, Jorge MD, FACP*Infectious Diseases in Clinical Practice: May 2013 - Volume 21 - Issue 3 - p e7–e9 doi: 10.1097/IPC.0b013e31826e7f79 Case Reports Abstract Author Information Abstract: Herpes simplex virus, an uncommon etiologic agent causing hepatitis, has been described in immunosuppressed, neonates, or pregnant patients as a fulminant disease with a relentless and fatal course in untreated individuals. Nonspecific signs and symptoms such as fever, anorexia, nausea, vomiting, abdominal pain, mucocutaneous lesions, elevations of aminotransferases, and leukopenia characterize herpetic hepatitis. We present a case of hepatic failure secondary to herpes simplex virus in a 35-year-old woman with human immunodeficiency virus infection in which definitive diagnosis was performed postmortem, with autopsy findings of massive hepatic necrosis with herpetic cytopathic effect and positive immunoperoxidase stains. Owing to its high mortality and available treatment, awareness and knowledge of this rare disease are critical for its early consideration in the differential diagnosis of any case of unexplained fulminant hepatitis. This will allow implementation of diagnostic tools, antiviral therapy, and referral for orthotopic liver transplantation, which proves lifesaving and positive impact prognosis. From the *Infectious Diseases Department, University Hospital and †Pathology Department, University of Puerto Rico School of Medicine, San Juan, PR. Correspondence to: Jorge Bertrán-Pasarell, MD, FACP, Infectious Diseases Program and Department of Medicine, University of Puerto Rico School of Medicine, PO Box 5067, San Juan, PR 00936-5067. E-mail: firstname.lastname@example.org. The authors have no funding or conflicts of interest to disclose. © 2013 by Lippincott Williams & Wilkins.