Skip Navigation LinksHome > March 2013 - Volume 21 - Issue 2 > Recurrence of SIADH With Localized Herpes Zoster Infection
Infectious Diseases in Clinical Practice:
doi: 10.1097/IPC.0b013e3182699166
Case Reports

Recurrence of SIADH With Localized Herpes Zoster Infection

Cerejo, Russell MD*; Kovacs, Christopher Jr MD; Hatipoglu, Betul MD

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Abstract: Localized herpes zoster (HZ) is rarely associated with a concomitant syndrome of inappropriate antidiuretic hormone secretion (SIADH). We present the case of 59-year-old woman being treated for chronic lymphocytic leukemia who had 2 separate episodes of localized HZ complicated by simultaneous SIADH. No other identifiable cause of SIADH was identified. Hyponatremia improved with antiviral therapy, and resolution paralleled improvement in skin lesions in both instances. This represents a unique situation of documented recurrence of SIADH with relapsed HZ. Clinicians should consider the possibility of concomitant SIADH in a patient with localized HZ even in the absence of symptoms. We suggest that the severity of HZ manifestations and the degree of hyponatremia may be positively correlated. Further investigation into the pathophysiologic mechanism for this association is warranted.

© 2013 by Lippincott Williams & Wilkins.

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