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Infectious Diseases in Clinical Practice:
doi: 10.1097/IPC.0b013e318260221b
Case Reports

Dose-Related Clinical Efficacy of Polymyxin B in a Critically Ill Patient

Singh, Manisha MBBS; Vilsaint, My-Charllins MD; Quale, John MD

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Abstract

Abstract: Published dosing schemes call for reduced dosage of polymyxin B for patients with renal insufficiency. However, recent evidence suggests that clearance of polymyxin B is not affected by renal function. We report a patient with renal insufficiency who had microbiological failure when adjusted dosing was administered but clearance of bacteremia when the dose was increased to that recommended for a patient with normal renal function.

© 2013 by Lippincott Williams & Wilkins.

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