Abstract: We describe a patient who presented with arthralgia, dyspnea, and edema and was subsequently diagnosed with parvovirus B19 infection. His hospital course was complicated by acute kidney injury, anemia, and significant volume overload. Diagnosis was made by polymerase chain reaction and serology. Treatment was supportive and resulted in complete resolution. This case illustrates both common and unusual manifestations of parvovirus infection. We suggest two different mechanisms by which parvovirus infection can result in anasarca. Parvovirus infection should be on the differential for acute unexplained generalized edema.