Abstract: Patients with hematologic malignancy are in a state of immunocompromise either due to the disease or as result of treatment. They are at risk for opportunistic fungal infections. The usual agents implicated are Aspergillus and Fusarium species. Patients with infected skin lesions are at risk of endogenous dissemination, and the eye can be one of the potential sites of infection due to hematogenous Fusarium dissemination. We describe 3 immunocompromised patients with hematologic malignancy who developed endogenous fusarial endophthalmitis.