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Infectious Diseases in Clinical Practice:
doi: 10.1097/IPC.0b013e3182506d8f
Case Reports

Successful Use of Intrathecal Daptomycin to Treat Meningitis Due to Vancomycin-Resistant Enterococcus faecium

Kahler, Ralph C. MD*; Holloway, Katherine PharmD, BCPS

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Abstract: Central nervous system infections are frequently associated with cerebrospinal fluid shunting procedures. Although most infections associated with central nervous system shunting procedures are caused by staphylococci, enterococci, including vancomycin-resistant enterococci, are increasingly a cause of nosocomial and community-acquired infections. We report a case in which a combination of intravenous and intrathecal daptomycin successfully eradicated vancomycin-resistant Enterococcus faecium infection of a cerebrospinal fluid shunt in a 59-year-old woman. In our patient, intrathecal daptomycin at a dose of 5 mg every 3 days resulted in microbiologic improvement 6 days after the initiation of therapy without a clinically significant rise in creatine phosphokinase levels.

© 2012 Lippincott Williams & Wilkins, Inc.

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