Abstract: Nontuberculous mycobacteria (NTM) may cause skin and soft tissue infections. Frequently, these are related to contaminated environmental sources and/or inappropriate disinfection of instruments (including reuse of single use devices). Reports of skin and soft tissue infections caused by NTM have been described in the setting of cosmetic procedures (especially those performed by unlicensed and/or untrained practitioners). Injection-related NTM infections rarely involve Mycobacterium marinum. We report 2 cases of Mycobacterium marinum facial ulcers after “filler” injections by an unlicensed practitioner at a local “spa.” Lack of suspicion of NTM association led to delayed diagnosis and extensive local destruction. We aim to increase education regarding NTM-related infections resulting from cosmetic injections and increase public vigilance regarding the appropriate setting and personnel performing these procedures.