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Infectious Diseases in Clinical Practice:
doi: 10.1097/IPC.0b013e318245d48f
Case Reports

Successful Treatment of Progressive Multifocal Leukoencephalopathy With Interferon

Horn, Andreas MD*†; Greene, John N. MD, FACP‡§

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Abstract

Abstract: Progressive multifocal leukoencephalopathy is usually a fatal demyelinating disease of the central nervous system caused by the John Cunningham (JC) virus with a median survival time of less than 5 months. We report about a patient that had typical clinical and radiological signs of progressive multifocal leukoencephalopathy, as well as positive in situ hybridization for JC virus of brain tissue, that was successfully treated with interferon α. The patient did largely outlive the usual prognosis of the disease, and no progress of clinical symptoms or radiological findings could be found after treatment.

© 2012 Lippincott Williams & Wilkins, Inc.

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