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Clostridium septicum Panophthalmitis Complicated by Meningitis: A Case Report and Review of the Literature

Slenker, Amy K. MD; DeSimone, Joseph A. MD

Infectious Diseases in Clinical Practice: September 2012 - Volume 20 - Issue 5 - p 305–308
doi: 10.1097/IPC.0b013e31824f8a6d
Review Articles

Abstract: Clostridium septicum is an anaerobic, gram-positive bacillus that can be found in the gastrointestinal tract of healthy subjects. It is an uncommon pathogen that is associated with malignancy and a high mortality rate. We present a case of C. septicum panophthalmitis complicated by meningitis, likely secondary to a prolapsing ileocecal valve polyp. To our knowledge, this is the first case of C. septicum panophthalmitis complicated by microbiologically confirmed meningitis reported in the literature. In addition, we review the existing 16 cases of C. septicum central nervous system and 6 cases of C. septicum ophthalmologic infections from the literature.

From the Division of Infectious Diseases and Environmental Medicine, Department of Medicine, Thomas Jefferson University, Philadelphia, PA.

Correspondence to: Amy K. Slenker, MD, Division of Infectious Diseases and Environmental Medicine, Department of Medicine, Thomas Jefferson University Hospital, 211 S. 9th St, Suite 210, Philadelphia, PA 19107. E-mail: amy.slenker@jeffersonhospital.org.

The authors have no funding or conflicts of interest to disclose.

© 2012 Lippincott Williams & Wilkins, Inc.