Abstract: Clostridium septicum is an anaerobic, gram-positive bacillus that can be found in the gastrointestinal tract of healthy subjects. It is an uncommon pathogen that is associated with malignancy and a high mortality rate. We present a case of C. septicum panophthalmitis complicated by meningitis, likely secondary to a prolapsing ileocecal valve polyp. To our knowledge, this is the first case of C. septicum panophthalmitis complicated by microbiologically confirmed meningitis reported in the literature. In addition, we review the existing 16 cases of C. septicum central nervous system and 6 cases of C. septicum ophthalmologic infections from the literature.