Abstract: Salmonella is an organism typically associated with gastrointestinal disease after exposure to contaminated food. Reptiles are also known reservoirs of Salmonella. Infrequently, Salmonella can cause extraintestinal infections and, rarely, infections involving the neck. Here, we report a case of cervical lymphadenitis in a boy caused by Salmonella enterica subsp diarizonae (Serogroup IIIb), an isolate associated with pet snakes, after direct exposure to a snake at an educational event at his school. Although evaluation of this child’s immune system was normal, it may be important to consider specific primary immunodeficiencies in children with invasive Salmonella infections caused by rare serotypes.