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Recurrent Localized Aspergillus Esophagitis in a Patient With Acquired Immunodeficiency Syndrome Who Failed Caspofungin Therapy

Ramanan, Poornima MD*; Sivapalan, Vel MD, FACP*; Schechter, Menachem MD; Culpepper-Morgan, Joan MD

Infectious Diseases in Clinical Practice:
doi: 10.1097/IPC.0b013e318255d43e
Case Reports

Abstract: Candida esophagitis is a common complication of AIDS, usually presenting with odynophagia. We report the case of a young woman with persistent symptoms despite antifungal therapy who was found to have invasive Aspergillus infection isolated to the esophagus, which promptly resolved with the introduction of lipid complex amphotericin. This case highlights the need to consider fungi other than Candida in the immunosuppressed patient with esophagitis, especially if unresponsive to first-line therapy.

In Brief

Ramanan et al. report the case of a young woman with AIDS and Aspergillus esophagitis who presented with persistent odynophagia despite antifungal therapy. This case highlights the need to consider fungi other than candida in immunocompromised patients with odynophagia, especially if unresponsive to first line therapy.

Author Information

From the Departments of *Infectious Diseases and †Gastroenterology, Harlem Hospital Center, Columbia University, New York, NY.

Correspondence to: Poornima Ramanan, MD, 1 Herrick Dr, Old Tappan, NJ 07675. E-mail

The authors have no funding or conflicts of interest to disclose.

© 2012 Lippincott Williams & Wilkins, Inc.