Abstract: Of the 2 species of Chromobacterium, Chromobacterium violaceum has been rarely implicated in human disease. It is a bacterium of low virulence causing occasional localized infection and sepsis. We report a case of C. violaceum infection of pancreatic pseudocyst. The patient was treated by cystojejunostomy with Roux-en-Y jejunal loop and antimicrobial therapy with ciprofloxacin and amikacin. As sepsis due to this organism is associated with high mortality, empiric therapy with fluoroquinolones and aminoglycosides is recommended, along with proper surgical management.