Abstract: Methicillin-resistant Staphylococcus aureus is an emerging pathogen in hospital nurseries and maternity units but has remained an unusual cause of invasive peripartum disease including chorioamnionitis. A 20-year-old woman at 30 weeks’ estimated gestational age presented to the hospital with fever, premature rupture of membranes, vaginal bleeding, and shortly spaced uterine contractions. Placental abruption was diagnosed, and emergency cesarean section was performed. A 1502-g infant girl was delivered with 1- and 5-minute Apgar scores of 8 and 8. Placenta was sent for culture and pathological examination. Placental culture revealed pure growth of methicillin-resistant S. aureus, and pathological examination showed chorioamnionitis, funisitis, and chorionic plate vessel vasculitis. We review our patient and all previously reported patients and present their epidemiology, manifestations, microbiologic data, and clinical outcomes.