Abstract: Echinococcosis represents a near-cosmopolitan parasitic zoonosis produced by adult or larval forms of the cestode helminthes of the genus Echinococcus. A long-term growth of metacestode (hydatid) cysts inside the intermediate hosts is characteristic of the larval infection known as hydatid disease or hydatidosis. We present the case of a 5-year-old boy admitted in 2005 to a pediatric clinic in Timisoara (Western Romania) and found with multiple hepatic and a renal hydatid cysts, human immunodeficiency virus, and giardiasis. After 3 surgical interventions managed by percutaneous aspiration, injection, reaspiration technique and chemotherapy with albendazole, the outcome was favorable. To date, this is the first case reported in the literature that summarizes all the aforementioned pathological aspects and consequently could represent an interesting challenge for both infectious disease practitioners and surgeons.