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Reiss, Kim A. MD*; Lanzkron, Sophie MD†; Holland, Steven M. MD‡; Westergaard, Ryan P. MD, MPH§; Fischer, William A. II MD∥
Abstract: Infection with nontuberculous mycobacteria is an important complication among patients with underlying immunosuppression or structural lung disease. Disseminated nontuberculous mycobacterial infection most commonly occurs in severely immunocompromised patients. We report a case of a patient with sickle cell disease who developed disseminated Mycobacterium avium complex and was successfully treated with a 12-month course of azithromycin and ethambutol. Testing for interferon gamma receptor defects failed to demonstrate additional causes of underlying immunodeficiency.
© 2012 Lippincott Williams & Wilkins, Inc.
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Mycobacterium avium complex, sickle cell disease, interferon gamma, interleukin 12
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