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Disseminated Mycobacterium avium Complex in an Immunocompetent Host: A Case Report

Reiss, Kim A. MD*; Lanzkron, Sophie MD; Holland, Steven M. MD; Westergaard, Ryan P. MD, MPH§; Fischer, William A. II MD

Infectious Diseases in Clinical Practice:
doi: 10.1097/IPC.0b013e318234c3e3
Case Reports
Abstract

Abstract: Infection with nontuberculous mycobacteria is an important complication among patients with underlying immunosuppression or structural lung disease. Disseminated nontuberculous mycobacterial infection most commonly occurs in severely immunocompromised patients. We report a case of a patient with sickle cell disease who developed disseminated Mycobacterium avium complex and was successfully treated with a 12-month course of azithromycin and ethambutol. Testing for interferon gamma receptor defects failed to demonstrate additional causes of underlying immunodeficiency.

Author Information

From the *Department of Internal Medicine, and †Division of Hematology, Department of Internal Medicine, Johns Hopkins University School of Medicine;‡National Institutes of Health, Bethesda; §Divisions of Infectious Diseases, and ∥Pulmonary and Critical Care Medicine, Department of Internal Medicine, Johns Hopkins University School of Medicine, Baltimore, MD.

Correspondence to: Kim A. Reiss, MD, Department of Internal Medicine, Johns Hopkins University School of Medicine, 600 North Wolfe St, Nelson Building, Room 434, Baltimore, MD 21287. E-mail: kreiss1@jhmi.edu.

Work was performed at Johns Hopkins University School of Medicine and at the National Institutes of Health.

The authors have no funding or conflicts of interest to disclose.

© 2012 Lippincott Williams & Wilkins, Inc.